p53 pathway tagged posts

Acne and telomere length. A new spectrum between senescence and apoptosis pathways. Journal of Investigative Dermatology, 2016; DOI: 10.1016/j.jid.2016.09.014

Scientists at King’s College London have found that people who have previously suffered from acne are likely to have longer telomeres (the protective repeated nucleotides found at the end of chromosomes) in their white blood cells, meaning their cells could be better protected against aging. Telomeres are repetitive nucleotide sequences found at the end of chromosomes which protect them from deteriorating during the process of replication. Telomeres gradually break down and shrink as cells age, eventually leading to cell death which is a normal part of human growth and aging...

Inhibition of Mdm2–MdmX RING–RING interaction by MMRi6 and its analog MMRi64.

A new class of small-molecule compounds has been discovered that are good candidates for novel targeted therapies in leukemia and lymphoma Rx. They drive cancer cells to suicide, RPCI researchers report. “We are excited about the unique activities of these compounds and will continue to focus our research efforts on development of their clinical potential,” says Xinjiang Wang, PhD. “These compounds kill cancer cells, not just stop cancer cell growth temporarily. These types of agents offer the promise of therapeutic benefit.”

They demonstrated that the small-molecule MMRi compounds have an advantage over p53-activating agents in current use as cancer therapies...