Do more with one link - claim and personalize your FREE link today! Effortlessly schedule, video meet, message chat, network, share materials, e-sign, etc – all in one spot. Collaborate, Nurture connections, Improve client services, Expedite deal closures, and more. 💼 Join FREE!!

Recent Comments

    paclitaxel tagged posts

    Molecular Trojan Horse delivers Chemotherapeutic drug to Cancer cells

    February 24, 2018, Categories  Biology/Biotechnology, Health/Medical

    Schematic illustration of the developed cancer targeting agent -- 123B9 in this study. The compound (right panel) has a scorpion-like shape with two arms grabbing EphA2-expressing cancer cells, and a tail (brown) constituted by a cytotoxic chemotherapeutic agent (paclitaxel used in this work). The agent would recognize the surface of cancer cells rich in EphA2 (labeled in red in the left panel which shows cancer cells) and deliver the cytotoxic agent. Credit: Pellecchia lab, UC Riverside.

    Schematic illustration of the developed cancer targeting agent — 123B9 in this study. The compound (right panel) has a scorpion-like shape with two arms grabbing EphA2-expressing cancer cells, and a tail (brown) constituted by a cytotoxic chemotherapeutic agent (paclitaxel used in this work). The agent would recognize the surface of cancer cells rich in EphA2 (labeled in red in the left panel which shows cancer cells) and deliver the cytotoxic agent. Credit: Pellecchia lab, UC Riverside.

    A research team at the University of California, Riverside has discovered a way for chemotherapy drug paclitaxel to target migrating, or circulating, cancer cells, which are responsible for the development of tumor metastases...

    Read More

    Scientist identifies Mechanism underlying Peripheral Neuropathy

    April 14, 2016, Categories  Biology/Biotechnology, Health/Medical

    MMP-13 inhibition improves adult paclitaxel-induced neurotoxicity. (A) Improved touch response upon coadministration of paclitaxel and either DB04760 or CL-82198 following four injections (n = 7, 7–12 fish per group) and complete rescue by day 14 in DB04760 coadministered animals (n = 2, 5 fish). (B and C) Axon branch density in distal caudal fin is rescued upon coadministration of paclitaxel and either DB04760 or CL-82198 when assessed 1 d (B) (n = 3, 7–12 fish per group) or 10 d (C) (n = 2, 5 fish per group) after the last injection. (D and E) MMP-13 immunofluorescence staining (red) 1 d after the last injection shows MMP-13 up-regulation specifically in basal keratinocytes (yellow arrowheads) of Tg(tp63:CAAX-GFP) fish injected with paclitaxel (E) and low MMP-13 expression in vehicle controls (D). Imaging was performed using identical settings. Dermal cells in both vehicle and paclitaxel-injected fish have similar MMP-13 expression levels. White arrowheads depict large distinctive MMP-13 clusters. (E) White arrows depict clusters of MMP-13–positive cellular debris at the skin surface, indicative of increased cell shedding. (Scale bar, 5 µm.) (F) MMP-13 staining (red) is adjacent to, but not within, DRG axons (green). (Scale bar, 10 µm.) *P < 0.05, ***P < 0.001, ****P < 0.0001. ac-tub, acetylated tubulin; Pctx, paclitaxel.

    MMP-13 inhibition improves adult paclitaxel-induced neurotoxicity. (A) Improved touch response upon coadministration of paclitaxel and either DB04760 or CL-82198 following four injections (n = 7, 7–12 fish per group) and complete rescue by day 14 in DB04760 coadministered animals (n = 2, 5 fish). (B and C) Axon branch density in distal caudal fin is rescued upon coadministration of paclitaxel and either DB04760 or CL-82198 when assessed 1 d (B) (n = 3, 7–12 fish per group) or 10 d (C) (n = 2, 5 fish per group) after the last injection...

    Read More

    Researchers Kill Drug-Resistant Lung Cancer with 50 times Less Chemo

    January 14, 2016, Categories  Biology/Biotechnology, Health/Medical

    Drug-resistant lung cancer cells are in red. Paclitaxel-loaded exosomes (green) swarm the cancer cells and bypass their drug resistance. Credit: UNC Eshelman School of Pharmacy

    Drug-resistant lung cancer cells are in red. Paclitaxel-loaded exosomes (green) swarm the cancer cells and bypass their drug resistance. Credit: UNC Eshelman School of Pharmacy

    The cancer drug paclitaxel just got more effective. For the first time, researchers from the University of North Carolina at Chapel Hill have packaged it in containers derived from a patient’s own immune system, protecting the drug from being destroyed by the body’s own defenses and bringing the entire payload to the tumor. “That means we can use 50 times less of the drug and still get the same results,” said A/Prof Elena Batrakova, Ph.D...

    Read More