pan-AKT inhibitors tagged posts

AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity. eLife, 2018 DOI: 10.7554/eLife.30640.001

New study sheds light on key protein. For 5 years, the assistant professor of integrative physiology at CU Boulder has been working to better understand a protein called AKT, which is ubiquitous in brain tissue and instrumental in enabling the brain to adapt to new experiences and lay down new memories. Until now, scientists have known very little about what it does in the brain. But in a new paper funded by the National Institutes of Health, Hoeffer and his co-authors spell it out for the first time, showing that AKT comes in 3 distinct varieties residing in different kinds of brain cells and affecting brain health in very distinct ways...