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Protecting Beta Cells against Stress may guard against Type 1 Diabetes

Genome-scale in vivo CRISPR screen identifies RNLS as a target for ...
Genome-scale CRISPR–Cas9 screen identifies Rnls as a modifier of beta cell survival in the NOD mouse model.

An existing drug boosts survival for insulin-producing cells under autoimmune attack. Researchers have found an unusual strategy that eventually may help to guard transplanted beta cells or to slow the original onset of type 1 diabetes.

Type 1 diabetes occurs when a person’s own immune system destroys insulin-producing beta cells in the pancreas. In recent years, scientists have learned how to grow large volumes of replacement beta cells, but the researchers are still trying out many options to protect these cells against the immune attack...

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