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    Parkin tagged posts

    Widespread Tumor Suppression Mechanism Stops Cancer Progression by interfering with cancer cell Metabolism

    August 26, 2021, Categories  Biology/Biotechnology, Health/Medical

    Novel Parkin ubiquitome in cancer.(A) Bioinformatics analysis of predicted protein networks regulated by Parkin ubiquitination in the absence of mitochondrial uncoupling, including cell death (HK1, MCL1, and HMGB1), glucose metabolism involving glycolysis (HK1 and TPI1) and the PPP (TALDO1 and TKT), protein folding (CCT7 and HSPA1A, also known as HSP72), and mitochondrial dynamics (RHOT1, FIS1, and MFN2). Parkin-directed ubiquitination sites (Lys, K) identified by SILAC proteomics in each target protein are indicated. (B) PC3 cells in the presence or absence of Parkin were immunoprecipitated with an antibody to MFN2, and immune complexes were probed with antibodies to ubiquitin (Ub) or MFN2 by Western blotting. IP, immunoprecipitation; IB, immunoblot. (C) The conditions are as in (B) exce...
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    PINK1 protein crucial for removing broken-down energy reactors

    August 12, 2015, Categories  Biology/Biotechnology, Health/Medical

    PINK1 and parkin are key regulators of mitochondrial quality control. Credit: http://www.sciencedirect.com/.../pii/S0166223614000435

    PINK1 and parkin are key regulators of mitochondrial quality control. Credit: http://www.sciencedirect.com/…/pii/S0166223614000435

    >> potential new pathway to treat ALS, other diseases. When mitochondia are damaged, they leak destructive molecules that can cause substantial harm and eventually kill brain cells. PINK1, a protein implicated in Parkinson’s disease is critical for helping cells get rid of dysfunctional mitochondria, by triggering an intricate process called mitophagy that breaks down and removes damaged mitochondria from the cell.

    “PINK1 is a flag of damaged mitochondria,” said Richard Youle, Ph.D., the head of the Biochemistry Section of NINDS. “It identifies which mitochondria need to be eliminated to keep cells healthy...

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