PARP1-DBC1 bonds tagged posts

A solid bond: New research led by Harvard Medical School reveals that interaction between the protein DBC1 and the signaling molecule NAD+ may help ward off DNA damage. Photo credit: David Bolinsky, e.mersion studios, 2017 

DNA repair is essential for cell vitality, survival and cancer prevention, yet cells’ ability to patch up damaged DNA declines with age for reasons not fully understood. Now, research led by scientists at Harvard Medical School reveals a critical step in a molecular chain of events that allows cells to mend their broken DNA. The findings offer a critical insight into how and why the body’s ability to fix DNA dwindles over time and point to a previously unknown role for the signaling molecule NAD as a key regulator of protein-to-protein interactions in DNA repair...