Parvalbumin-positive interneurons tagged posts

Mice lacking a set of receptors in one type of neuron in the brain developed compulsive, anti-social behaviors. Parvalbumin-positive interneurons, thought to be important in general cognition and generating certain types of oscillatory wave patterns in the brain. “We found that without this receptor in the parvalbumin cells, mice have many serious behavioral deficits,” says Terrence Sejnowski, head of Salk’s Computational Neurobiology Laboratory, “And a lot of them really mimic closely what we see in schizophrenia.”

Scientists had previously discovered that when molecular signaling was disrupted in these cells during development, the brain’s networks didn’t form correctly...