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    pathogenic bacteria tagged posts

    Pathogenic Bacteria use a Sugar in the Intestinal Mucus Layer to Infect the Gut, study shows

    July 5, 2023, Categories  Biology/Biotechnology, Health/Medical

    The Citrobacter rodentium (orange) rely on sugars in the intestinal mucus layer (green).
    Harmful gut bacteria like Citrobacter rodentium (orange) rely on sugars in the intestinal mucus layer (green).

    A new study by researchers at the University of British Columbia (UBC) and BC Children’s Hospital shows the sugar sialic acid, which makes up part of the protective intestinal mucus layer, fuels disease-causing bacteria in the gut.

    The findings, published in PNAS, suggest a potential treatment target for intestinal bacterial infections and a range of chronic diseases linked to gut bacteria, including inflammatory bowel disease (IBD), celiac disease, IBS and short bowel syndrome.

    “Bacteria need to find a place in our intestines to take hold, establish and expand, and then they need to overcome all the different defenses that normally protect our gut,” says Dr...

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    New Study puts Gut Microbiome at the Center of Parkinson’s Disease Pathogenesis

    January 11, 2023, Categories  Biology/Biotechnology, Health/Medical

    Fig. 2
     PD-associated species nominated by consensus of MaAsLin2 and ANCOM-BC. Analysis included N = 724 biologically independent samples from 490 PD and 234 neurologically healthy control (NHC) subjects. a 257 species (denoted by circles in the plot) were tested in microbiome-wide association study (MWAS) with two statistical methods: MaAsLin2 and ANCOM-BC. The results are shown according to significance (−log10 of the FDR) achieved by MaAslin2 (Y-axis) vs ANCOM-BC (X-axis). Corresponding untransformed FDR values are provided in parentheses on the X and Y axes for easier interpretation. 84 species were nominated as PD-associated, defined by FDR < 0.05 by one method and FDR≤0.1 by the other: 68 achieved FDR < 0.05 by both methods, 10 achieved ANCOM-BC MaAsLin2 FDR < 0.05 by MaAsLin2 and FDR≤0...
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