peptide major histocompatibility complexes (pMHC) tagged posts

‘Relaxed’ T Cells Critical to Immune Response

Rice University scientists’ simple model of T cell activation of the immune response shows the T cell binding, via a receptor (TCR) to an antigen-presenting cell (APC). If an invader is identified as such, the response is activated, but only if the “relaxation” time of the binding is long enough. Illustration by Hamid Teimouri

Like finding that needle in the haystack every time, your T cells manage what seems like an improbable task: Quickly finding a few invaders among the many imposters in your body to trigger its immune response.

T cells have to react fast and do so nearly perfectly to protect people from diseases. But first, they need a little “me” time.

Rice University researchers suggest that has to do with how T cells “relax” in the process of binding to ligands—shor...

Read More