A single tau monomer encodes different assembly conformations that each leads to distinct patterns of pathology.
Credit: UT Southwestern
Scientists who recently identified the molecular start of Alzheimer’s disease have used that finding to determine that it should be possible to forecast which type of dementia will develop over time – a form of personalized medicine for neurodegenerative diseases.
A new study from UT Southwestern shows that single toxic tau proteins that stick together and spread degeneration across the brains of dementia patients have different shapes. The folds of these molecules hold information that could help diagnose – and perhaps one day treat – neurodegeneration in its earliest stages.
The finding comes from a team of scientists appointed this month to a newly c...
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