photodynamic therapy tagged posts

Astronomers Help Wage War on Cancer

A model showing light (red/yellow) penetrating the surface of the human breast (white triangles). Credit: T. Harries

A model showing light (red/yellow) penetrating the surface of the human breast (white triangles). Credit: T. Harries

Techniques developed by astronomers could help in the fight against breast and skin cancer. A large part of astronomy depends on the detection and analysis of light. For example, scientists study the light scattered, absorbed and re-emitted in clouds of gas and dust, obtaining information on their interior.

Despite the vast differences in scale, the processes that light undergoes when travelling through the human body are very similar to those seen in space. And when things go wrong – when tissue becomes cancerous – that change should show up.

In the UK, nearly 60,000 women are diagnosed with breast cancer each year, and 12,000 die...

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Simply Shining Light on ‘Dinosaur Metal’ compound Kills Cancer Cells

Iridium with its organic coat which is hooked up to the protein albumin (HSA). Together that enter cancer cells and deliver the iridium photosensitizer to the nucleus. On irradiation with blue light, the iridium not only glows green, but converts oxygen in the cell to a toxic form called triplet oxygen, which kills the cell.
Credit: University of Warwick

A new compound based on Iridium, a rare metal which landed in the Gulf of Mexico 66 M years ago, hooked onto albumin, a protein in blood, can attack the nucleus of cancerous cells when switched on by light, University of Warwick researchers have found...

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Advance in Photodynamic Therapy offers new Approach to Ovarian Cancer

Intraoperative ovarian cancer treatment based on the combinatorial effect of a targeted photodynamic therapy (PDT) associated with suppression of the DJ-1 protein, one of the key players in the ROS defense of cancer cells. Ovarian cancer tumors exposed to a single dose of combinatorial therapy were completely eradicated from the mice and the treated animals showed no evidence of cancer recurrence.

Intraoperative ovarian cancer treatment based on the combinatorial effect of a targeted photodynamic therapy (PDT) associated with suppression of the DJ-1 protein, one of the key players in the ROS defense of cancer cells. Ovarian cancer tumors exposed to a single dose of combinatorial therapy were completely eradicated from the mice and the treated animals showed no evidence of cancer recurrence.

A combination of techniques by Oregon State University researchers achieved complete cancer cell elimination with no regrowth of tumors. It may offer a novel mechanism to address this aggressive and often fatal cancer that kills 14,000 women in the US each year. Ovarian cancer has a high mortality rate because it often has metastasized into the abdominal cavity before it’s discovered...

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