photoreceptors tagged posts

Seeing Better by Looking Away

Lead author
Lead author – Jenny L. Reiniger taking measurements on the laser ophthalmoscope© Volker Lannert/Uni Bonn

A study suggests that we fixate slightly away from the retinal optimum to see better. When we fixate an object, its image does not appear at the place where photoreceptors are packed most densely. Instead, its position is shifted slightly nasally and upwards from the cellular peak. This is shown in a recent study conducted at the University of Bonn (Germany), published in the journal Current Biology. The researchers observed such offsets in both eyes of 20 healthy subjects, and speculate that the underlying fixation behavior improves overall vision.

We like to think of the eye as a camera, but the analogy falls short if we look at the distribution of light sensitive cells — phot...

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New Eye Drops may prevent a common cause of Blindness

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Credit: International Gemini Observatory/NOIRLab/NSF/AURA/P. Marenfeld


Researchers at Columbia University Irving Medical Center have developed eye drops that could prevent vision loss after retinal vein occlusion, a major cause of blindness for millions of adults worldwide.A study, in mice, suggests that the experimental therapy — which targets a common cause of neurodegeneration and vascular leakage in the eye — could have broader therapeutic effects than existing drugs.The study was published in Nature Communications.What is Retinal Vein Occlusion?Retinal vein occlusion occurs when a major vein that drains blood from the retina is blocked, usually due to a blood clot...

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Researchers Rescue Photoreceptors, Prevent Blindness in animal models of Age-Related Macular Degeneration

The researchers will take a patient’s own blood cells, and in a lab, convert them into iPS cells capable of becoming any type of cell in the body. The iPS cells are then programmed to become retinal pigment epithelial cells, the type of cell that dies early in the geographic atrophy form of AMD.
Credit: National Eye Institute

Findings set stage for first clinical trial of stem cell-based therapeutic approach for AMD. Using a novel patient-specific stem cell-based therapy, researchers at the National Eye Institute (NEI) prevented blindness in animal models of geographic atrophy, the advanced “dry” form of age-related macular degeneration (AMD), which is a leading cause of vision loss among people age 65 and older. The protocols established by the animal study, published Jan...

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Human Retinas grown in a Dish explain how Color Vision develops

Temporally regulated TH signaling specifies cone subtypes. (A) Embryonic stem cell–derived human retinal organoids [wild type (WT)] generate S and L/M cones. Blue, S-opsin; green, L/M-opsin. (B) Organoids that lack thyroid hormone receptor β (Thrβ KO) generate all S cones. (C) Early activation of TH signaling (WT + T3) specifies nearly all L/M cones. (D) TH-degrading enzymes (such as DIO3) expressed early in development lower TH and promote S fate, whereas TH-activating regulators (such as DIO2) expressed later promote L/M fate.

Temporally regulated TH signaling specifies cone subtypes.
(A) Embryonic stem cell–derived human retinal organoids [wild type (WT)] generate S and L/M cones. Blue, S-opsin; green, L/M-opsin. (B) Organoids that lack thyroid hormone receptor β (Thrβ KO) generate all S cones. (C) Early activation of TH signaling (WT + T3) specifies nearly all L/M cones. (D) TH-degrading enzymes (such as DIO3) expressed early in development lower TH and promote S fate, whereas TH-activating regulators (such as DIO2) expressed later promote L/M fate.

Biologists at Johns Hopkins University grew human retinas from scratch to determine how cells that allow people to see in color are made...

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