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    Study identifies Cause of Disruption in Brain linked to Psychiatric Disorder including Schizophrenia

    August 18, 2015, Categories  Biology/Biotechnology, Health/Medical

    Dopamine-dependent long term depression of mediated transmission profoundly disrupts normal synaptic transmission between hippocampus and PFC. These results show how dopaminergic activation induces long-term hypofunction of NMDARs, which can contribute to disordered functional connectivity, a characteristic that is a hallmark of psychiatric disorders such as schizophrenia.

    Dopamine-dependent long term depression of mediated transmission profoundly disrupts normal synaptic transmission between hippocampus and PFC. These results show how dopaminergic activation induces long-term hypofunction of NMDARs, which can contribute to disordered functional connectivity, a characteristic that is a hallmark of psychiatric disorders such as schizophrenia. Credit: https://neurowiki2012.wikispaces.com/file/view/Reward_circuit.jpg/315908202/Reward_circuit.jpg

    New research reveals mechanisms that trigger disruption in the brain’s communication channels linked to symptoms in psychiatric disorders. This research could have important implications for treating symptoms of brain disorders.

    Many of our everyday cognitive functions such as learning and memory rely on normal communic...

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