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Left: The 23 pairs of chromosomes of cells in which autophagy is functioning look normal and healthy with no structural or numerical aberrations (each color represents a unique chromosome pair). Right: the chromosomes of cells in which autophagy is not functioning bypass crisis, showing both structural and numerical aberrations, with segments added to, deleted from, and/or swapped between chromosomes–a hallmark of cancer. Credit: Salk Institute
Cellular recycling process, thought to fuel cancer’s growth, can actually prevent it. Scientists studying the relationship of telomeres to cancer made a surprising discovery: a cellular recycling process called autophagy – generally thought of as a survival mechanism – actually promotes the death of cells, thereby preventing cancer initiation.
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