Overall structure of human PrimPol ternary complex with template-primer DNA and incoming dATP. The N-helix and modules ModN and ModC are shown in cartoon representation in dark blue, yellow, and cyan, respectively. The DNA is shown as gray sticks, and the Ca2+ ion is shown as a light blue sphere. The templating base T and the incoming dATP are shown in red. Yellow and cyan dashed lines depict unstructured regions in the ModN and ModC, respectively. The side chains of key catalytic active-site residues Asp114, Glu116, and Asp280 are highlighted in red. Secondary structure elements (α helices and β strands) are labeled in black.
A research team led by scientists at the Icahn School of Medicine at Mount Sinai (ISMMS) has solved the 3D structure of a key protein that helps damaged cellular D...
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