Progranulin and TMEM106B genetic variants tagged posts

Brain-Aging Gene discovered

Stock image credit: Getty Images

Asa Abeliovich, Herve Rhinn et al. Genetic determinants of aging in human brain. Cell Systems, 2017 DOI: 10.1016/j.cels.2017.02.009 Stock image credit: Getty Images

Genetic variant accelerates normal brain aging in older people by up to 12 years. Columbia University Medical Center (CUMC) researchers have discovered a common genetic variant that greatly impacts normal brain aging, starting at around age 65, and may modify the risk for neurodegenerative diseases. The findings could point toward a novel biomarker for the evaluation of anti-aging interventions and highlight potential new targets for the prevention or treatment of age-associated brain disorders such as Alzheimer’s disease.

“If you look at a group of seniors, some will look older than their peers and some will look younger,” sai...

Read More