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    Six-hour ‘undo’ button: GAI-17 rewinds stroke damage and may beat Alzheimer’s

    July 23, 2025, Categories  Biology/Biotechnology, Health/Medical

    Beneficial effects of GAPDH-C152A expression and GAI-17 on acute ischemic stroke treatment in model mice
    Ischemia-Reperfusion-induced GAPDH aggregates lead to cell death and paralysis, but both GAPDH-C152A expression and GAI-17 treatment can decrease the chances of post-stroke side effects.
    Credit: Osaka Metropolitan University

    Protein aggregation inhibitor shows lower levels of cell death and paralysis in mice with acute strokes.

    Stroke kills millions, but Osaka researchers have unveiled GAI-17, a drug that halts toxic GAPDH clumping, slashes brain damage and paralysis in mice—even when given six hours post-stroke—and shows no major side effects, hinting at a single therapy that could also tackle Alzheimer’s and other tough neurological disorders.

    Stroke is said to be the se...

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