PFF limits spread of glioblastoma multiforme, or GBM – the most common primary tumor of the brain and CNS by targeting protein TROY. In addition, TGen lab research also found PPF increases effectiveness of a standard-of-care chemotherapy drug called temozolomide (TMZ), and radiation, to treat glioblastoma. “We showed that PPF decreased glioblastoma cell expression of TROY, inhibited glioma cell invasion, and made brain cancer cells more vulnerable to TMZ and radiation,” said Dr. Nhan Tran, Ass Prof and head of TGen’s Central Nervous System Tumor Research Lab.
An advantage of small-molecule PPF – previously used in clinical trials in an attempt to treat Alzheimer’s disease and dementia – is that it can penetrate the blood-brain barrier and reach the tumor...
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