psoriasis tagged posts

Skin’s Protective Chains uncovered

Structures and nomenclature of human ceramide classes. A and B: Structures of LCBs (A) and FAs (B) in human ceramides. The abbreviations used in this study are shown in parentheses after each compound name, and those recommended by LIPID MAPS (https://www.lipidmaps.org) are shown below them, with each number corresponding to an n value of 1 or 15, as indicated in the figure. Two models have been proposed for how protein-bound ceramides bind to corneocyte envelope proteins

The skin’s top layer contains a diverse set of hundreds of lipid molecules called ceramides with varying chain lengths that play a vital role in its barrier function.

Ceramides are a type of lipid that are found in abundance in the top layer of the skin, called the stratum corneum...

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Scientists discover Link between Gut Microbiota and Chronic Inflammatory Diseases like Arthritis

An international research team has established a link between gut microbiota and chronic inflammatory diseases such as arthritis. The team led by Éric Boilard of Université Laval has discovered that a protein naturally present in the gut acts on the microbiota and causes the formation of molecules that exacerbate the symptoms of these diseases. The details of this finding are published today in the Journal of Clinical Investigation — Insight.

The protein in question, phospholipase A2-IIA, was discovered several years ago in the fluid that surrounds the joints of people with arthritis according to Dr. Boilard, a professor in the Faculty of Medicine at Université Laval and a researcher at CHU de Québec-Université Laval Research Centre...

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Suffering from Psoriasis? Blame this Trio of Proteins

New study shows there may be a way to help even more psoriasis patients. About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes. Although there are effective treatments for psoriasis, not everyone responds to these therapies — and for many, the relief is temporary.

“These therapies don’t reduce disease by 100 percent, and they don’t cure the disease” says La Jolla Institute for Immunology (LJI) Professor Michael Croft, Ph.D. “And if you take patients off those drugs, the disease almost always comes back.”

Now Croft and his team in LJI’s Center for Autoimmunity and Inflammation have discovered how a key protein called TWEAK damages skin cells in psoriasis patients...

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Detecting Skin Disorders based on Tissue Stiffness with a Soft Sensing Device

The research team designs a simple, miniature electromechanical device for high-precision and real-time evaluations of deep tissue stiffness. (Photo source: Dr Yu Xinge’s team)

A research team has designed a simple electromechanical device that can be used for deep tissue pathology diagnosis, such as psoriasis, in an automated and non-invasive fashion. The findings will lay a foundation for future applications in the clinical evaluation of skin cancers and other dermatology diseases.

By putting a piece of soft, strain-sensing sheet on the skin may be able to detect skin disorders non-invasively and in real-time very soon.

The research is co-led by Dr Yu Xinge, Assistant Professor from CityU’s Department of Biomedical Engineering, and scientists from and Northwestern University ...

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