PUMA tagged posts

Opposite effect: Protein widely known to Fight Tumors also Boosts Cancer Growth

UC San Diego researchers found that the PUMA protein works inside the cell’s mitochondria to switch energy production processes and stimulate cancer growth.
Credit: Xu Lab, UC San Diego

Researchers find evidence that genome ‘guardian’ can stimulate cancer. Researchers studying p53, the heralded cancer-fighting ‘guardian of the genome,’ found that the human protein also plays a role in promoting tumors, in addition to suppressing them. They found that the PUMA protein works inside the cell’s mitochondria to switch energy production processes and stimulate cancer growth. Search for a description of “p53” and it becomes clear that this human protein is widely known for its cancer-fighting benefits, leading to its renown as “the guardian of the genome.”

Scientists at the University of Ca...

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