Purkinje cells tagged posts

Image reveals Purkinje cells (gray) and their dendrites, as well as an accumulation of protein deposits (red dots). Credit: Ackerman Lab/UC San Diego

Protein ‘proofreading’ errors lead to neurodegenerative disease. UCSD researchers found that the ‘Ankrd16’ gene acts like a failsafe in proofreading and correcting errors to avoid the abnormal production of improper proteins. Usually, the information transfer from gene to protein is carefully controlled – biologically “proofread” and corrected – to avoid the production of improper proteins...