pyruvate carboxyl tagged posts

Staying Young, from the Cells On Up

A rendering of the enzyme complex named HTC
CREDIT: CHUM

Scientists discover a new enzymatic complex that can stop cells from aging, opening the way to possible new cancer therapies. Researchers at Université de Montréal and McGill University have discovered a new multi-enzyme complex that reprograms metabolism and overcomes “cellular senescence,” when aging cells stop dividing.

In their study published today in Molecular Cell, the researchers show that an enzyme complex named HTC (hydride transfer complex) can inhibit cells from aging.

“HTC protects cells from hypoxia, a lack of oxygen that normally leads to their death,” said senior author Gerardo Ferbeyre, an UdeM biochemistry professor and principal scientist at the CRCHUM, the university’s affiliated teaching hospital resea...

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