Micrograph showing emphysema (left – large empty spaces) and lung tissue with relative preservation of the alveoli (right). Credit: Wikipedia
New research suggests that FPS-ZM1, an antagonist chemical compound that fights RAGE (the receptor for advanced glycation end-products), may treat COPD. In mice it was found this compound reverses the inflammatory response and has a protective role in COPD. “RAGE disturbances in pulmonary disorders are precise and effective strategies with beneficial clinical effects,” said Se-Ran Yang, D.V.M., Ph.D. Kangwon National University, Korea.
In their study, Yang and colleagues investigated the efficacy of RAGE-specific antagonist FPS-ZM1 administration in both in vivo and in vitro COPD models to determine the molecular mechanism by which RAGE influences ...
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