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    RBFox1 tagged posts

    New Discovery could Aid Regenerative Heart Therapies

    December 28, 2023, Categories  Biology/Biotechnology, Health/Medical

    The top row depicts immature human heart muscle cells generated from stem cells. Their shape and fibre organisation is irregular.
    The top row depicts immature human heart muscle cells generated from stem cells. Their shape and fibre organisation is irregular.  Upon Rbfox1 expression, the cells, as seen in the lower row, are more organised, closer to the shape and organisation of mature muscle cells in an adult heart. (Credit: [Huang J, Lee JZ, Rau CD, et al. Regulation of postnatal cardiomyocyte maturation by an RNA splicing regulator rbfox1. Circulation. 2023;148(16):1263-1266. doi: 10.1161/circulationaha.122.061602)

    Researchers identify RBFox1 as a key intrinsic regulator of heart muscle cell maturation, overcoming a major limitation in cardiac regenerative therapy and disease modelling and demonstrating for the first time that RNA splicing control can significantly impact this process.

    Scientists led by Duk...

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    Scientists find a Stem-cell derived Mechanism that could lead to Regenerative Therapies for Heart Damage

    October 20, 2023, Categories  Biology/Biotechnology, Health/Medical

    Heart

    A UCLA-led team has identified an essential internal control mechanism that can promote the maturation of human stem cell-derived heart muscle cells, offering a deeper understanding of how heart muscle cells develop from their immature fetal stage to their mature adult form.

    The findings, published in the journal Circulation, could lead to new therapies for heart disease and cardiac damage.

    The collaborative effort with Duke-NUS Medical School in Singapore and other institutions identified an RNA splicing regulator named RBFox1, which was considerably more prevalent in adult heart cells than in newborns, based on a preclinical model. The sharp rise in RBFox1 during the maturation of heart cells was also confirmed through analyses of existing single-cell data.

    “This is the fir...

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