•A spider silk domain boosts p53 translation in vitro
•The spider silk-p53 fusion protein adopts a compact state and is biologically active
•Reducing N-terminal disorder in fusion proteins increases expression and stability
The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet in Sweden have now found an unusual way of stabilising the protein and making it more potent. By adding a spider silk protein to p53, they show that it is possible to create a protein that is more stable and capable of killing cancer cells. The study is published in the journal Structure.
P53 plays a key r...
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