ATF6 is protective in the heart; it is expressed at high levels in the young heart, and low levels in the aged heart. Gene therapy studies that were done in the Glembotski lab at the SDSU Heart Institute have shown that restoring ATF6 in the aged mouse heart to levels in the young heart provides remarkable protection against heart disease, and could pave the way for development of this therapy for use in humans in the near future. Credit: Chris Glembotski
A protein found in the heart that is known to be involved in cellular stress responses in cancer cells is now believed to play a critical role in the ability of cardiac cells to combat heart disease and recover from a heart attack...
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