reduction in MCT4 tagged posts

Cancer cells. Credit: Dr. Cecil Fox, National Cancer Institute

Cancer researchers seeking non-toxic alternatives to harmful chemotherapy are reporting a highly significant result for a humble cold remedy. N-Acetyl cysteine – or NAC – is routinely used as a dietary supplement and as a decongestant given to children to ward off a cold. Now, clinical trials in the US indicate the cheap, over-the-counter drug, is a first rate inhibitor of the tumour stroma, a cell compartment which is fundamental to the spread of cancer. The results, published in Seminars in Oncology, confirm a long-held theory that cancer cells are being sustained and strengthened by the presence of MCT4, a protein which ‘brings them’ energy, in the form of lactate, from neighbouring cells.

Patients taking high dosages of NAC...