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Mean pure-tone air-conduction thresholds in the treated ear of all patients that completed 12 weeks follow-up (N = 42). Presented timepoints are baseline (black), 6 (blue) and 12 (red) weeks, error bars indicate standard deviations. Pure-tone thresholds are displayed in decibel hearing level (dB HL), frequency in kilohertz (kHz). Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-45784-0
Researchers at UCL and UCLH have successfully completed the first trial of a therapy designed to restore hearing loss. The REGAIN trial, the results of which were published in Nature Communications, was the first study of a treatment aimed at restoring lost hearing, focusing on a drug with the technical name gamma-secretase inhibitor LY3056480.
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