Nicotinamide Riboside (NR)
Nicotinamide riboside rejuvenates stem cells, allowing better regeneration processes in aged mice. As mice, like all mammals, age, the regenerative capacity of certain organs (eg liver and kidneys) and muscles (including the heart) diminishes. Their ability to repair them following an injury is also affected. This leads to many of the disorders typical of aging.
Hongbo Zhang wanted to understand how the regeneration process deteriorated with age. To do so, he teamed up with colleagues from ETH Zurich, the Uni of Zurich and universities in Canada and Brazil. Through several markers, he was able to identify the molecular chain that regulates how mitochondria function and how they change with age...
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