regulatory T cells tagged posts

Comparison of plasma antibody responses. When compared with the A.Control group, the A.bnAb group had higher binding to HIV-1 Env gp120 (A) and gp41 (B) but similar binding (C) to TIV2008. Binding was similar between the B.bnAb and B.Control groups for the same three antigens (D to F). NS, not significant. Each symbol represents data from an individual participant; group medians, range, and quartiles are shown.

Findings provide insight for vaccine development. People living with HIV who naturally produce broadly neutralizing antibodies (bNAbs) that may help suppress the virus have different immunological profiles than people who do not...

Histologic assessment of arthritic joints using hematoxylin and eosin staining revealed a higher arthritis score on Tph1−/−mice

For the 1st time, serotonin (5-hydroxytryptamine, 5-HT) has been directly implicated in the pathophysiology of rheumatoid arthritis (RA). Although 5-HT is predominantly known as a neurotransmitter within the CNS, new evidence points to additional important functions for serotonin in the periphery. A report in The American Journal of Pathology shows that experimentally-induced RA in serotonin-deficient mice is worse than disease reported in controls and that some effects of RA can be reduced by serotonin or its agonists (compounds that activate serotonin receptors).

“Our study highlights that 5-HT has a direct immunoregulatory role in arthritis...