REM sleep tagged posts

‘Goldilocks’ Neurons promote REM Sleep

Using a technique called optogenetics, a laser light was used to turn off or on MCH neurons time locked with the temperature warming phases. It demonstrated the necessity of the MCH neurons to increase REM sleep during warming toward “just right” room temperature. Picture: Pascal Gugler for Insel Gruppe AG

It has been a mystery why REM sleep, or dream sleep, increases when the room temperature is ‘just right’. Neuroscientists show that melanin-concentrating hormone neurons within the hypothalamus increase REM sleep when the need for body temperature defense is minimized, such as when sleeping in a warm and comfortable room temperature. These data have important implications for the function of REM sleep.

Every night while sleeping, we cycle between two very different states of sleep...

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Dreams Turned Off and On with a Neural Switch

stimulating dream sleep

When a laser triggers an optogenetic switch in neurons in the medulla of a sleeping mouse, the animal goes from non-REM sleep (NREM) into REM or dream sleep. The axons of these neurons (green) reach into distant parts of the primitive brain, such as the hypothalamus, broadly affecting brain function. (Franz Weber image.)

Activating small group of neurons in medulla causes rapid transition to REM sleep. The researchers inserted an optogenetic switch into a group of nerve cells located this area, allowing them to activate or inactivate the neurons with laser light. When the neurons were activated, sleeping mice entered REM sleep within seconds...

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