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    Scientists Identify potential ‘Guardian’ against Neurodegeneration

    January 26, 2016, Categories  Biology/Biotechnology, Health/Medical

    Highlights •The three isoforms of mammalian Tet3 include Tet3FL, Tet3s, and Tet3o •The CXXC domain of Tet3 is a specific reader of 5-carboxylcytosine at CcaCG sequences •The crystal structure of the CXXC domain-5caC complex was solved •Tet3FL in neurons targets genes of the lysosome and base excision repair pathways

    Highlights •The three isoforms of mammalian Tet3 include Tet3FL, Tet3s, and Tet3o •The CXXC domain of Tet3 is a specific reader of 5-carboxylcytosine at CcaCG sequences •The crystal structure of the CXXC domain-5caC complex was solved •Tet3FL in neurons targets genes of the lysosome and base excision repair pathways

    Stopping disruptions in cellular “trash removal” brought on by errors in molecular marks on DNA may guard against neurodegenerative diseases like Parkinson’s. Novel findings from a team led by Van Andel Research Institute (VARI) Professor Gerd Pfeifer, Ph.D., implicate certain epigenetic modifications in the development of some neurodegenerative diseases...

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