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Researchers discover the Source of New Neurons in Brain’s Hippocampus

The dentate gyrus of mouse hippocampus at postnatal day 7, blue is nuclei marker, green is progeny of HOPX-expressing progenitor cells, and red is marker of cell proliferation.
Credit: Daniel A. Berg and Allison M. Bond

Findings extend understanding of how a continuous supply of neurons throughout life is connected with learning and memory. Researchers have shown, in mice, that one type of stem cell that makes adult neurons is the source of this lifetime stock of new cells in the hippocampus. These findings may help neuroscientists figure out how to maintain youthful conditions for learning and memory, and repair and regenerate parts of the brain after injury and aging.

“We’ve shown for the first time, in mammals, that neurons in the dentate gyrus of the hippocampus grow and develo...

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