Highlights •atRA deficiency in colon cancer is driven by microbiota-induced inflammation •Treatment with atRA reduces tumorigenesis by enhancing a CD8+ T cell response •The enhanced CD8+ T cell response is due to upregulation of MHCI on tumor cells •CD8+ T cell cytotoxicity in human colon cancer correlates with local atRA metabolism
Mice with the cancer have lower-than-normal levels of the metabolite in their gut. Furthermore, colorectal cancer patients whose intestinal tissues express high levels of a protein that degrades retinoic acid tend to fare more poorly than their peers. The research is the first to unravel a complicated dance between retinoic acid levels, immune-related inflammation and gut microorganisms...
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