Images: 1. RHEB, Ras homolog enriched in brain  2. BACE1
TSRI Florida scientists have made an important discovery toward the development of drugs to treat age-related memory loss in diseases like Alzheimer’s. They found that reduced levels of a protein called Rheb result in spontaneous symptoms of memory loss in animal models and are linked to increased levels of another protein known to be elevated in the brains of Alzheimer’s disease patients. Subramaniam’s group investigated the link between Rheb and an important enzyme called BACE1, which is elevated in older adults and people with Alzheimer’s disease.
“We know that Rheb regulates BACE1, which is a major drug target in Alzheimer’s disease,” Subramaniam said...
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