ribosomal DNA tagged posts

In the absence of SIRT7, a human primary cell displays multiple nucleoli. DNA was stained with DAPI (turquoise) and nucleolus was stained with anti-fibrillarin (red).

Aging is a process of gradual deterioration from exposure to time and the elements; this process begins with deterioration deep inside every cell. Researchers from Stanford University and the VA Palo Alto Health Care System (VAPAHCS) have identified a protein that guards cells against senescence – aging-related problems – by protecting a particularly vulnerable set of genes. The study is published in the July 13 issue of the Journal of Biological Chemistry.

The genes that encode components of the ribosome – the protein-making machine of the cell – are abundant and constantly in use...

When offspring are in the womb, what their mothers experience environmentally (for example, diet, stress, smoking), influences the attributes of offspring when they are adults. This ‘developmental programming’ is understood to be a large contributor to the obesity epidemic seen today. Credit: © highwaystarz / Fotolia

The process by which a mother’s diet during pregnancy can permanently affect her offspring’s attributes, such as weight, could be strongly influenced by genetic variation in an unexpected part of the genome, according to research led by Queen Mary University of London (QMUL). The discovery could shed light on why many human genetic studies have previously not been able to fully explain how certain diseases, such as type 2 diabetes and obesity, are inherited.

The study shows g...