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    NAD⁺ restores memory in Alzheimer’s disease models by correcting RNA errors

    November 13, 2025, Categories  Biology/Biotechnology, Health/Medical

    NAD⁺ restores memory in Alzheimer's' disease models by correcting RNA errors
    NR induces transcription of genes involved in axon development, oxygen metabolism, mitochondrion localization, and autophagy in tauopathy mice. GO terms enriched in each of the eight classes of clusters in (A); each circular bar graph represents one cluster or class of clusters, and bar length correlates with the number of DEGs represented. GO terms shown in red font relate to mRNA. Clusters 4 and 5 are similar and are grouped together. Class 1 includes clusters 1, 2, and 6 marked with red. Class 2 includes clusters 4 and 5 marked with orange. Class 3 includes cluster 8 marked with yellow. GTPase, guanosine triphosphatase; NAD(P)H, reduced form of NAD phosphate; IRES, internal ribosomal entry site; GTP, guanosine 5′-triphosphate; MHC, major histocompatibility complex. Credit: Science A...
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