Inhibition of transcriptional interference with siRNA. The top panel depicts how GNG12-AS1 modulates the expression of the active DIRAS3 allele through transcriptional interference. GNG12-AS1 may act as a rheostat for DIRAS3 transcription rate. The lower panel depicts how exogenous siRNA molecules in a complex with AGO2 can bind to both the TSS and GNG12-AS1 to inhibit Pol II, and block further transcription initiation and elongation of GNG12-AS1. As a result of transcriptional silencing of GNG12-AS1, transcriptional interference is reduced leading to increased transcription of DIRAS3.
Supposed non-coding DNA, found in between genes, plays a role in suppressing cancer, according to new research by Universities of Bath and Cambridge...
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