The immune system protein SARM1 (red) extends to the string-like fibers (axons) of nerve cells in the brains of mice infected with La Crosse virus. Scientists are examining how SARM1 interacts with mitochondria in the axons to induce death of the nerve cells. Credit: NIAID
Many brain disorders involve the death of neurons, or nerve cells, but how these neurons die is not well understood. A new study describes how the activation of normally protective immune responses causes nerve cells to die and identifies the protein responsible, providing a potential target for therapeutic intervention.
Researchers from NIH’s National Institute of Allergy and Infectious Diseases (NIAID) studied the effect of immune system proteins: toll-like receptors on neurons...
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