SARS-CoV-2 tagged posts

Study links Severe COVID-19 to Increase in Self-Attacking Antibodies

An illustration of antibodies among blood cells.
SciePro/Shutterstock.com

Hospitalized COVID-19 patients are substantially more likely to harbor autoantibodies than people without COVID-19, according to a new study. Autoantibodies can be early harbingers of full-blown autoimmune disease. “If you get sick enough from COVID-19 to end up in the hospital, you may not be out of the woods even after you recover,” said PJ Utz, MD, professor of immunology and rheumatology at Stanford Medicine.

Utz shares senior authorship of the study, which will be published Sept...

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3D ‘Assembloid’ shows how SARS-CoV-2 infects Brain Cells

Figure depicts SARS-CoV-2 spreading through blood vessels (green) to infect pericytes (red), which amplify infection and can spread infection to other cell types in the brain.
CREDIT
UC San Diego Health Sciences

Researchers at University of California San Diego School of Medicine and Rady Children’s Institute for Genomic Medicine have produced a stem cell model that demonstrates a potential route of entry of SARS-CoV-2, the virus that causes COVID-19, into the human brain.

The findings are published in the July 9, 2021 online issue of Nature Medicine.

“Clinical and epidemiological observations suggest that the brain can become involved in SARS-CoV-2 infection,” said senior author Joseph Gleeson, MD, Rady Professor of Neuroscience at UC San Diego School of Medicine and director of n...

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Human Lung and Brain Organoids respond differently to SARS-CoV-2 Infection in Lab Tests

brain and lung organoids
UC San Diego School of Medicine researchers found approximately 10-fold higher SARS-CoV-2 infection (green) in lung organoids (left), compared to brain organoids (right).

Findings may help explain the wide variety in COVID-19 symptoms and aid search for therapies. COVID-19, the disease caused by the pandemic coronavirus SARS-CoV-2, is primarily regarded as a respiratory infection. Yet the virus has also become known for affecting other parts of the body in ways not as well understood, sometimes with longer-term consequences, such as heart arrhythmia, fatigue and “brain fog.”

Researchers at University of California San Diego School of Medicine are using stem cell-derived organoids — small balls of human cells that look and act like mini-organs in a laboratory dish — to study how the ...

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Can you spread Covid-19 if you get the Vaccine?

We know that the vaccines now available across the world will protect their recipients from getting sick with Covid-19. But while each vaccine authorized for public use can prevent well over 50% of cases (in Pfizer-BioNTech and Moderna‘s case, more than 90%), what we don’t know is whether they’ll also curb transmission of the SARS-CoV-2 virus.

That question is answerable, though—and understanding vaccines’ effect on transmission will help determine when things can go back to whatever our new normal looks like.

The reason we don’t know if the vaccine can prevent transmission is twofold. One reason is practical...

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