In recent years, generating see-through tissue – a process called optical clearing -has become a goal for many researchers in life sciences because of its potential to reveal complex structural details of our bodies, organs, and cells – both healthy and diseased -when combined with advanced microscopy imaging techniques.
“The usefulness of optical clearing techniques can be measured by their ability to gather accurate 3D structural information that cannot be readily achieved through traditional 2D methods,” explains Atsushi Miyawaki. “Here, we achieved this goal using a new procedure, and collected data that may resolve several current issues regarding the pathology of Alzheimer’s disease...
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