MIT researchers have developed a new way to image proteins and RNA inside neurons of intact brain tissue. Image: Yosuke Bando, Fei Chen, Dawen Cai, Ed Boyden, and Young Gyu
Microscopy technique allows pinpointing RNA molecules in the brain. Key to the new technique is expanding the tissue before imaging it so it can be seen at very high resolution using ordinary microscopes commonly found in research labs. “Now we can image RNA with great spatial precision, thanks to the expansion process, and we also can do it more easily in large intact tissues,” says A/Prof Ed Boyden.
Studying the distribution of RNA inside cells could help scientists learn more about how cells control their gene expression and could also allow them to investigate diseases thought to be caused by failure of RNA to m...
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