seizures tagged posts

A team led by a biomedical scientist at the University of California, Riverside has found a new mechanism responsible for the abnormal development of neuronal connections in the mouse brain that leads to seizures and abnormal social behaviors.

The researchers focused on the hippocampus, which plays an important role in learning and social interactions; and synapses, specialized contacts between neurons.

Each neuron in the brain receives numerous excitatory and inhibitory synaptic inputs...

Jasmine M. McCammon, Alicia Blaker-Lee, Xiao Chen, Hazel Sive. The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. Human Molecular Genetics, 2017; DOI: 10.1093/hmg/ddx255

For the first time, Whitehead Institute scientists have documented a direct link between deletions in two genes – fam57ba and doc2a – in zebrafish and certain brain and body traits, such as seizures, hyperactivity, enlarged head size, and obesity. “Finding the molecular connections between a brain and a body phenotype is indeed really paradigm shifting,” says Whitehead Institute Member Hazel Sive, who is also a professor of biology at MIT...