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    Sema3A tagged posts

    How does Estrogen Protect Bones? Unraveling a pathway to menopausal bone loss

    March 23, 2019, Categories  Biology/Biotechnology, Health/Medical

    Estrogen induces osteocyte expression of Sema3A, which acts on its receptor on osteocytes to promote survival, resulting in reduced osteoclastic bone resorption and enhanced osteoblastic bone formation. Sema3A-activated sGC-cGMP signaling through Nrp1 protected osteocytes from apoptosis.
    Credit: Department of Cell Signaling,TMDU

    Women who have reached menopause are at a greater risk of developing osteoporosis, which can lead to bone fractures and long-term impairment of mobility. Studies have suggested a link between reduced bone density and low estrogen levels due to menopause, but the basis for this link is unclear. Researchers found that the protein Sema3A plays a key role in maintaining healthy bones, suggesting a new therapeutic avenue to treat osteoporosis.

    Bone is a complex...

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