sepsis tagged posts

Scientists working in the School of Biochemistry and Immunology in the Trinity Biomedical Sciences Institute at Trinity College Dublin have made an important breakthrough in understanding what goes wrong in our bodies during the progression of inflammatory diseases and – in doing so – unearthed a potential new therapeutic target.

The scientists have found that an enzyme called Fumarate Hydratase is repressed in macrophages, a frontline inflammatory cell type implicated in a range of diseases including Lupus, Arthritis, Sepsis and COVID-19.

Professor Luke O’Neill, Professor of Biochemistry at Trinity is the lead author of the research article that has just been published in leading international journal, Nature. He said:

“No-one has made a link from Fumarate Hydratase to infla...

Patients are 20% less likely to die of sepsis because a new AI system developed at Johns Hopkins University catches symptoms hours earlier than traditional methods, an extensive hospital study demonstrates.

The system, created by a Johns Hopkins researcher whose young nephew died from sepsis, scours medical records and clinical notes to identify patients at risk of life-threatening complications. The work, which could significantly cut patient mortality from one of the top causes of hospital deaths worldwide, is published today in Nature Medicine and npj Digital Medicine.

“It is the first instance where AI is implemented at the bedside, used by thousands of providers, and where we’re seeing lives saved,” said Suchi Saria, founding research director of the Malone Center for Engin...

Researchers are developing a ground-breaking method that uses biomarkers to detect sepsis 2 to 3 days before the first clinical symptoms appear. This can significantly increase the chances of survival in cases of blood poisoning by bacteria or fungi.

Whether activating or silencing genes, breaking down defective cells or building new tissue, our body is constantly working to repair itself, even in cases of illness. To fight a disease, our body sends out signals, often long before we ourselves notice the disease...

Construction of a tissue-specific protein abundance atlas. (a) Vascularized organs, plasma and cells adjacent to the blood plasma were collected from healthy Balb-C mice. The collected organs and cells were washed in PBS, homogenized, the proteins digested with trypsin and analysed by shotgun LC-MS/MS. (b) The scaled spectral counts from the LC-MS/MS analysis of the individual organs and cells were correlated using Pearson’s r correlation coefficient, indicated by the numbers in the heat map. (c) Heat map of the scaled spectral counts of the different cell and organs. The grey lines in the heat map shows percentage of signal associated with a given organ or cell type. Total number of identified proteins per organ, blood vessel and cells is shown in brackets below the heat map.

Research g...