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    High-Fat Diet in Pregnancy can cause Mental Health Problems in Offspring

    July 24, 2017, Categories  Biology/Biotechnology, Health/Medical

    Figure 8. (A) The location of area 10 of the prefrontal cortex (PFC) was determined using figures from Paxinos Stereotaxic Atlas (39). DAPI staining was used to differentiate the layers of the cortex, numbered 1–6. (B) Representative images of the differences seen in 5-HT fiber innervation of medial area 10 of the PFC between the four diet groups. (C) Exposure to a postweaning high-fat diet (HFD) decreased mean intensity of 5-HT immunoreactive signal in layer 1 of medial area 10 in the PFC (F1,16 = 7.662, p = 0.014). (D) 5-HT immunoreactivity in the same region was further affected by an interaction between gender and postweaning diet (F1,16 = 7.497, p = 0.015), with mean intensity decreased in postweaning HFD males compared to control males (F1,16 = 13.895, p = 0.002). Data shown as mean ± SEM. # denotes a postweaning diet effect, p < 0.05. Scale bars are 400 µm. Sample sizes for the 5-HT immunohistochemisty are as follows: CTR/CTR n = 6 (n = 2 males; n = 4 females), CTR/HFD n = 6 (n = 3 males; n = 3 females), HFD/CTR n = 6 (n = 3 males; n = 3 females), and HFD/HFD n = 6 (n = 3 males; n = 3 females).

    (A) The location of area 10 of the prefrontal cortex (PFC) was determined using figures from Paxinos Stereotaxic Atlas (39). DAPI staining was used to differentiate the layers of the cortex, numbered 1–6. (B) Representative images of the differences seen in 5-HT fiber innervation of medial area 10 of the PFC between the four diet groups. (C) Exposure to a postweaning high-fat diet (HFD) decreased mean intensity of 5-HT immunoreactive signal in layer 1 of medial area 10 in the PFC (F1,16 = 7.662, p = 0.014). (D) 5-HT immunoreactivity in the same region was further affected by an interaction between gender and postweaning diet (F1,16 = 7.497, p = 0.015), with mean intensity decreased in postweaning HFD males compared to control males (F1,16 = 13.895, p = 0.002). Data shown as mean ± SEM...

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