sIgM tagged posts

Antibody sIgM emerges as a key guardian of gut health and metabolism

Oriol Sunyer pointing to rainbow trout, the fish species used for the reported study.
Oriol Sunyer pointing to rainbow trout, the fish species used for the reported study.
Image: Courtesy of Penn Vet

A pioneering new study published in Nature Microbiology, led by J. Oriol Sunyer, professor of immunology and pathobiology at the School of Veterinary Medicine, and a team of researchers at Penn Vet and the University of New Mexico, has uncovered a surprising new player in gut health: an antibody called secretory immunoglobulin M (sIgM).

While another antibody, secretory immunoglobulin A (sIgA), has long been known for helping balance the bacteria in our intestines, this new research shows that sIgM may be just as vital—if not more so—in protecting gut health and maintaining overall well-being.

Secretory immunoglobulins—immunoglobulins found in the mucosal surfaces ...

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