Single-Cell RNA Sequencing tagged posts

Humans and other animal species can experience many types of pain throughout the course of their lives, varying in intensity, unpleasantness, and origin. Several past neuroscience studies have explored the neural underpinnings of pain, yet the processes supporting the ability to distinguish different types of physical pain are not fully understood.

In most vertebrates, painful sensations are known to arise from the nervous system, which includes the brain, an intricate network of nerves and the spinal cord...

Researchers at Karolinska Institutet in Sweden have studied which genes are expressed in overactive immune cells in mice with asthma-like inflammation of the airways. Their results, which are published in the journal Immunity, suggest that the synthesis and breakdown of fats plays an important part in the process.

In asthma, the immune system is overactive, causing inflammation in the lungs and symptoms such as coughing, wheezing and shortness of breath. The Th2 cell plays a vital part in asthma-related inflammation, but the rarity of these cells and a lack of sensitivity technology has made these cells hard to study in any detail.

Resear...