Sirt6-dependent differentially acetylated proteins tagged posts

How a key protein helps drive healthy longevity by maintaining a precise balance

One foot on the gas and one on the brake: How a key protein helps drive healthy longevity
Illustration of the one-carbon metabolic pathway. Sirt6-dependent differentially acetylated proteins are highlighted by red circles. Credit: Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.2514084122

Researchers at Bar-Ilan University have discovered how the longevity-associated protein Sirt6 orchestrates a delicate molecular balancing act that protects the body from age-related decline and disease. The new findings, just published in the Proceedings of the National Academy of Sciences, reveal how Sirt6 preserves health during aging and may pave the way for therapies that promote a longer, healthier life.

Sirt6, often described as a master regulator of aging, is known for its powerful protective effects against age-related diseases such as cancer, diabete...

Read More