Small-molecule drug tagged posts

A cross section of a mouse spinal cord, stained two different ways, showing increased expression of KCC2 in inhibitory neurons. This increased expression correlated with improved motor function, including ankle movement and stepping. Credit: Zhigang He Lab, Boston Children’s Hospital

Small-molecule drug reactivates dormant nerve pathways; could complement regenerative strategies. Most people with spinal cord injury are paralyzed from the injury site down, even when the cord isn’t completely severed. Why don’t the spared portions of the spinal cord keep working? Researchers at Boston Children’s Hospital now provide insight into why these nerve pathways remain quiet...